![]() Testotoxicosis affects fewer than one in a million men, and a leading expert estimates that we may only number in the hundreds. The result is premature everything: bone growth, muscle development, body hair, the full menu of dramatic physical changes that accompany puberty. The condition tricks the testicles into thinking the body is ready to go through puberty - so wham, the floodgates open and the body is saturated with testosterone. Having a mutant LHCGR gene leads to what doctors now call familial male-limited precocious puberty, an extremely rare disease that affects only men because you have to have testicles, which is why it’s also called testotoxicosis. But somewhere back in the lost recesses of my family’s genetic history, an unfortunate ancestor of mine was born with a mutant LHCGR gene. In women of reproductive age, the LHCGR triggers ovulation in men, it triggers testosterone production. On chromosome 2 in the DNA of all human beings, there’s a gene called the luteinizing hormone/choriogonadotropin receptor (LHCGR). We’ve all carried the same hereditary genetic mutation. It was the same for my father, and for his father, and for his father, and for the men in my family going back as far as we have records. There was no prelapsarian age of innocence for me I was born, I took a huge bite of the apple, and, by 2 years old, I was pretty much ready to get busy with Eve. I have no recollection of a time before puberty, before the carnal cravings, the impulses, the angst and anger and violence. I couldn’t talk, I could barely walk, but I started growing a bush. I got my first pubic hair when I was 2 years old.
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